Isco and Morata starred in the comeback against Villarreal and Zidane has conceded he needs to give them more game time.
Madrid came back from 2-0 to win 3-2 away. They scored all three goals in the final 26 minutes.
Isco was involved in all three goals, with Alvaro Morata scoring the winning goal with seven minutes left to play.
“There is no doubt that Isco and Morata deserve to get more minutes,” the Madrid boss told reporters.
“They did very well and changed the game for us. I’m certain that we will need to call on the whole squad.
“I gave Morata a couple of tactical bits of advice and told him he needed to be in the box to finish any chances and for him to stick on Bruno in the middle when we were defending.
“He got his goal and we are all happy. It was important for us to get the three points to remain top.”
Zidane added: “At 2-0 down we had to change something. We did so and it worked out well for us. We made an attacking change and enjoyed more possession in their half.
“We knew that we were coming up against a good side, who have being doing fantastically well at home. We had to be patient and our substitutions ended up changing the game. “