Manchester United will play their former striker in the Europa League after drawing Fenerbache in the group stages.
The Dutchman was at the Old Trafford club for three years before moving to Turkey in July 2015.
Southampton will be playing in the Europa League for the first time, and they will meet Inter Milan.
The full Europa League draw as follows:
Group A: Manchester United, Fenerbahce, Feyenoord, Zorya
Group B: Olympiacos, APOEL, Young Boys, Astana
Group C: Anderlecht, Saint-Etienne, Mainz, Qabala
Group D: Zenit, AZ Alkmaar, Maccabi Tel-Aviv, Dundalk
Group E: Viktoria Plzen, Roma, Austria Vienna, Astra
Group F: Athletic Bilbao, Genk, Rapid Vienna, Sassuolo
Group G: Ajax, Standard Liege, Celta Vigo, Panathinaikos
Group H: Shakhtar Donetsk, Braga, Gent, Konyaspor
Group I: Schalke, RB Salzburg, Kuban Krasnodar, Nice
Group J: Fiorentina, PAOK, Slovan Liberec, Qarabag
Group K: Inter, Sparta Prague, Southampton, Hapoel Be’er Sheva
Group L: Villarreal, Steaua Bucharest, FC Zurich, Osmanlispor