The UCL draw threw a twist and the UEL would not be outdone, as Klopp will be returning to former club Dortmund.
Dortmund were paired with Liverpool, who eliminated Manchester United, in the quarterfinals of the Europa.
Sevilla will face La Liga counterparts Athletic Club, as they look to hold on to the trophy.
While Villarreal will face Sparta Prague, with Shakhtar Donetsk getting Sporting Braga.
DRAW IN FULL
Sporting Braga vs Shakhtar Donetsk
Villarreal vs Sparta Prague
Athletic Bilbao vs Sevilla
Borussia Dortmund vs Liverpool