Adam Lallana is hoping Liverpool can record a victory over United when they meet.
Liverpool have played United four times this season and have lost all encounters.
Lallana can beat United when Liverpool play them in the Europa League last 16.
And the England international says he is desperate to see Liverpool reverse the form book and inflict a first defeat in this fixture on Red Devils boss Louis van Gaal.
“I’ve not won a game against Manchester United in my time here and we want to put that right,” Lallana told a pre-match news conference.
“I think it will be just like a Premier League game. It’s got the makings of a special tie.
“You don’t have to be local to understand the significance of this rivalry. You feel the importance in the build-up.”
United and Liverpool disappointingly lie sixth and seventh respectively in the Premier League, despite recent improvements in form.