Philip Cocu is confident PSV can qualify for the last eight against Atletico.
The match is even, with the first leg ending in a goalless draw last month.
Atletico have lost just one match at the Vicente Calderon in their last 16 matches.
However, Cocu is bullish over PSV’s chances of booking a spot in the last eight.
“The great atmosphere in [Estadio Vicente Calderon] can give us a power boost. In this stage of European football, all the stadiums where you play will be impressive in talks of ambiance,” Cocu told reporters.
“We want to silence the fans of Atletico with playing good football.
“We feel good after Ajax drew with NEC, but no we are not thinking about the Eredivisie because we have to concentrate on the Champions League. We have a good chance to reach the quarter-finals.
“Atletico are favourites because of their home advantage. It will be difficult, but it is not impossible to go through.”