Rooney starts in a very crucial match against Chelsea after coming on in the second half against Stoke and Hazard is back from injury.
Rooney came on in the second half of the boxing day loss to Stoke after a fall in form.
Hazard will be playing for the first time under new boss Hiddink after shaking off his injury.
Manchester United starting XI: De Gea; Darmian, Smalling, Blind, Young; Schneiderlin, Schweinsteiger; Mata, Herrera, Martial; Rooney.
Chelsea starting XI: Courtois; Ivanovic, Zouma, Terry, Azpilicueta; Mikel, Matic; Willian, Oscar, Pedro; Hazard.