The absence of Rooney due to injury as given Van Gaal the chance to pick Fellaini to start against West Ham.
Youth player Jesse Lingard is also recalled to the squad. With Ashley Young and Depay both getting the bench.
And the defensive line for United, boast of Blind at the left, with McNair and Smalling in the middle and Darmian on the right. Schweinstiger retains his spot and Mata gets to play.
West Ham, meanwhile, make four changes to their side with James Tomkins, Alex Son, Mark Noble and Andy Carroll coming in for Carl Jenkinson, Pedro Obiang, Manuel Lanzini and Diafra Sakho.
Man Utd XI: De Gea, Darmian, Smalling, McNair, Blind, Schneiderlin, Schweinsteiger, Mata, Lingard, Fellaini, Martial. Subs: Romero, Varela, Young, Borthwick-Jackson, Carrick, Pereira, Memphis.
West Ham: Adrian, Tomkins, Reid, Ogbonna, Cresswell, Song, Noble, Kouyate, Moses, Zarate, Carroll. Subs: Randolph, Jenkinson, Collins, Obiang, Oxford, Antonio, Jelavic.