Ahead of their match against Wolfsburg, united midfielder Morgan Schneiderlin has asked his teammates not to depend on CSKA for a chance at the knockout.
United can qualify for the last 16 if they win against Wolfsburg, but failure to do so and a win for PSV over CSKA will see them eliminated.
And Schneiderlin has asked his teammates to focus on getting a win against a Wolfsburg team who need just a draw to progress.
“It is [difficult to beat Wolfsburg] but we are confident we can do it,” the former Southampton midfielder told United Review.
“We beat them at home and, to go through to the next round, we do not want to hope for CSKA Moscow to win or get a result in Eindhoven.
“We have the destiny in our hands and know what we have to do to get through. It is very important for the football club and for the players to get to the next stage and we are going out to win in Wolfsburg.
“They are a very good team and it is never easy in Germany but we will prepare for this game as though it was the final of the Champions League.”
After United were absent from the Champions League last season, Schneiderlin is eager to see the club mark their return to Europe’s elite club competition by reaching the knockout stages.
“You know the best 16 teams in Europe are involved and we are looking forward to trying to put Manchester United in this category,” he said.
“Last year, we did not have the Champions League here so we are determined to get among the best teams in Europe.”
United are currently second in Group B, with one point less than leaders Wolfsburg and ahead of PSV by the same margin.