Both Marcelo and Ramos will be out of action, as Madrid will not be taking them along to face Shqkhtar Donetsk.
Marcelo picked up an adductor muscle problem from the clasico and Ramos aggravated his shoulder injury against Sevilla and Barcelona.
And now both have been dropped from the squad to travel to Shakhtat, a place Ramos picked up his injury.
Real Madrid squad in full:
Keylor Navas, Kiko Casilla, Ruben Yanez; Raphael Varane, Pepe, Nacho, Dani Carvajal, Danilo; Toni Kroos, James Rodriguez, Gareth Bale, Casemiro, Mateo Kovacic, Luka, Modric, Denis Cheryshev, Isco; Cristiano Ronaldo, Karim Benzema, Lucas Vazquez, Jese.