Mourinho has relegated several key players to the bench. With Eden Hazard left out of the starting eleven to face Aston Villa at Stamford Bridge.
Mourinho has opted to push Cesc Fabregas into a more advanced role. Diego Costa is back from suspension and leads the line of attack.
While Ruben Loftus-Cheek is preferred to Matic in the heart of midfield, with Ramires set to partner the youngster.
With Ivanovic out injured, Mourinho has opted to start right footed Azpilicueta at left back, while left footed summer signing, Baba Rahman is preferred at right back. Gary Cahill gets the bench.
Chelsea: Begovic; Baba, Terry, Zouma, Azpilicueta; Loftus-Cheek, Ramires; Willian, Fabregas, Pedro; Diego Costa. Subs: Blackman, Cahill, Matic, Mikel, Oscar, Hazard, Remy.
Aston Villa: Guzan; Hutton, Richards, Lescott, Richardson; Westwood, Gana; Gil, Grealish, Ayew; Gestede. Subs: Bunn, Bacuna, Sinclair, Traore, Amavi, Sanchez, Crespo.