United will be without Depay and Wilson for the clash against Crystal Palace, with both players out due to injury.
Depay started the League Cup match against Middlesbrough, a match United lost due to penalty, but Depay was substituted off in the 70th minute due to injury.
While Wilson was forced off and made to make way for Rooney at halftime due to an injury of his own.
“Memphis and Wilson both picked up injuries against Middlesbrough,” manager Louis van Gaal told MUTV.
“We will have to wait and see how they are.”
Antonio Valencia and Paddy McNair also remain sidelined and will definitely miss the trip to Palace.