France’s talismanic midfielder Franck Ribery is set to miss the 2014 World Cup with a back injury.
The Bayern Munich player, 31, has been ruled out after injuring his lower back in a training session on Friday.
“He is not capable of training for a few weeks, let alone playing a game,” Deschamps told a news conference.
Lyon’s Clement Grenier is also out with a hip injury, leading to a call-up for Southampton’s Morgan Schneiderlin.
The three-time French player of the year has been suffering from lower back pains for several weeks, playing only once for club or country since 29 April.